Ah! "but not the chemistry behind how they interact once mixed."....
Along similar lines to "What is the meaning of Life, The Universe, and Everything?"
As the Japanese distillers have pursued (to their definite and large advantage), modern chemistry allows PRECISE discovery of "what is in it?" for any liquid. Down to parts-per-billion precision and with total knowledge of component identification.
There are NO components in - for example - a Great malt whisky which cannot be acquired in pure form so that a duplicate "recipe" of ingredients can be made.
The Great Mystery is how these form over time in the environment inside an ageing barrel. And even that is no longer much of a mystery to the Chemistry Detectives.
Techniques have been available for DECADES to relatively mundane laboratories not only to identify and quantify ALL such components, and to also to TRACK whence they came.
Time-spanned repeat studies even show up "intermediates" along the way.
So, the scientifically inclined follow their path, sometimes with a quiet chuckle for the Traditionalists who insist that a good malt only develops if the right number of old bones are thrown into the air, at the right height and with the correct incantation.......
And the Traditionalists laugh in (near) total disbelief at the complete analysis of the Big Picture suggested by their opponents.
The big question is who, over time, makes the best product in terms of Customer acceptance AND preparedness to pay.
And PROFIT of course!
Which US Distilleries get $100 per 70cl bottle of single malt made on a COFFEY STILL (and know that even some in Scotland have done for many decades....https://en.wikipedia.org/wiki/Ben_Nevis_distillery )?
How many posters herein are actively and currently discussing and debating such progressive options to Process Improvement, compared to those promoting "same old" methodologies?
Sure ALL distilleries have seen gradual incorporation of newer ideas and technologies over the centuries.
What many seem to fail to grasp is the rate of ACCELERATION of such adoptions, and the rapid demise of those failing to see the "train" heading their way in their tunnel!
Cast your minds back to how impregnable DEC seemed with their super-mini computers in 1985. Or Compaq did with their PC's in 1995.
Both GONE. Extinct as the dinosaurs.
And all they did was to fall behind "the Curve" SET BY THEIR CUSTOMERS' NEEDS.
They both thought they owned their market. Both were seriously mistaken!
Just my $0.02