Don't know if I can help much but I've worked at a single malt distillery out in Canada that did a bit of grain bill experimentation (we were attached to a brewery). I've also heard one of the distillers at Glenmorangie talking about this - their whisky Signet was a bit of a source of inspiration at my old place and our experiences line up pretty well.
At least in my experience, I think you're probably getting a bit cute with this if you think (like in a brewery) that a change between 10% and 20% Vienna or Carapils is going to make any difference at all in an aged whisky. Off the top of my head, Signet was made with something like 40% chocolate malt, and we were pushing 50 to 60% chocolate malt in our mash. Basically, as much as we could get in the mash tun without extract falling ridiculously low. Despite this, we always wanted 'more' roast character - after a 5 year aging or whatever you need to bring the spirit to maturity, even a mashbill that tasted repulsively strong in the FV and was pot distilled and left 'rough' would lead to a subtle impact on finished spirit character. Anyway like I said I'm not an expert with non-roasted malts, but I figure if 60% chocolate malt doesn't have a massive impact on finished whisky flavour, crystal and especially Vienna/Munich malts will be almost undetectable.
For what it's worth in my new job making wheat/rye whisky we did a lot of testing of yeast strains when I started and that did lead to a slightly greater impact on new make character. Plus it's much easier (and cheaper) to implement into daily production than using specialty brewing malts. Whether it'll lead to great differences after aging I'm still slightly skeptical, but that probably depends what distillation methods and cask types you are using (we use a lot of new oak and it tends to take over even pretty rough whisky after a few years.)
All that said, you'll only know what works if you try it! It's definitely a lesser-explored area of whisky innovation - only, sometimes there's a reason for that.